The Nissan is a standard rwd. We plan on going up the 5 with a few jogs onto 99 to visit colleges my daughter has applied to. My brother has lived in the Seattle area for about four years and drives a 330i. He hasn't had any problems other than being careful with ice, but he doesn't have run flats.
I'm worried about the Cajon Pass (Southern CA) and the pass from CA into Oregon.