It would be a long day but you could drive the "tail of the dragon" in a day from there. I would guess it would take about 9 hours to drive from Greer to the dragon, run it a couple times, and drive back. You could take some scenic roads for at least part of the way. If you don't know what the dragon is, google it. 318 turns in 11 miles. Commercial photographers hide in the woods and take pictures you can buy from their websites. There is a gas station/convenience store on the NC side that sells t-shirts. My son and I ran it in 2010 from my house an hour and a half from Greer (further away) in about 12 hours. We took scenic roads when possible. If you stayed more on the interstate you could do it quicker.