I have S2 and runflats and haven't had any problems. Frankly speaking, I don't think the 2 things are related. I think what you read is the general sentiment on this board that the LS2 runflats are prone to bubbles and PSS tires are much better. Bottom line is you don't need to change the runflats to have S2.
14 Porsche Boxster S - http://www.porsche-code.com/PED27M31
12 BMW 550i xDrive (Dinan S5, Intercoolers, Exhaust, Springs/Shockware, Negative Camber/Low Compliance Arms & Intake; 3M CR40; AG M355, Michelin PSS & Tikore Ti Lugs) - Alpine White, Beige, M Sport, Cold Weather, Premium Sound, ARS, Sport Auto, Power Shades, Side/Top Cameras, HUD & BMW Apps.
13 Infiniti JX35 AWD - Fully Loaded
07 BMW 550i - Dinan S2 & CF Intake (Gone)
09 Hyundai Genesis 4.6 (Gone)