I've used BG244, which is the serious injector/fuel system cleaner. One quart should be enough to treat 2-3 full tanks on a 335d.
http://www.bgprod.com/catalog/diesel-fuel-system/bg-244/#bg-product-1
I'm also trying BG DFC Plus. Very concentrated stuff. One quart treats something like 250 gals of diesel fuel.
http://www.bgprod.com/catalog/diesel-fuel-system/bg-dfc-plus/#bg-product-5
My concept is to use BG244 every 25K miles to give the fuel system a serious cleaning, then treat occasionally with DFC Plus to keep it cleaned and other stated benefits. You can check the links above for the description of what each product does. The indy mechanic I have used for 20 years with my previous gas burning BMW's, was a big fan of the BG44k product. BG244 is the equivalent for diesel.
I think Optilube is kind of similar to DFC Plus in that it claims to add lubricity and improves cetane rating. Also helps in real cold temps, not normally a problem in the Southeast. I ordered a 6 pack of 8oz bottles and gave it a try based on recommendations by other diesel drivers, on other boards.
I think it is hard to make a data driven judgement on these products, but I can tell when I have additives in the tank of fuel. Generally, the engine seems to run quieter and a little "smoother". I also generally get about 1.5 - 2.0 mpg average better when I have the Optilube or DFC Plus in the fuel. For instance, when I have the additives, I average about 33.5-34.0 MPG for the entire tank during my normal commute. If I'm driving a pure highway trip with the additives, I will avg a solid 38 mpg for the entire tank, cruising at between 75-80 mph. Without the additives, I usually avg just over 32 mpg on the commute and won't normally exceed 36 mpg on a highway trip.
I think if you do the math, the cost of the additives won't be recovered just by the increase in fuel mileage. However, "if" they accomplish what they advertise, then the engine/fuel system should be better off due to being cleaner, better lubricated and running a little higher cetane than just ULSD alone.