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That's a really broad question, and subject to a lot of things. If you use 85 octane gas and never change the oil, it'll run for another 10k miles. If you regularly change the oil, fuel filters, spark plugs, coolant, etc etc etc etc etc etc etc it will last you forever*.
But, to answer the question I think you're asking- the M60 is trickier to work on than others due to the limited space in the engine bay and there are more electronics involved, so there are generally more issues with this engine than others. However, taken care of correctly (also assuming that the PO took care of it correctly), they'll take you to 300k+
*Included in the "etc etc etc etc" is several engine rebuilds, transmission replacements, and a huge amount of replacement parts.
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But, to answer the question I think you're asking- the M60 is trickier to work on than others due to the limited space in the engine bay and there are more electronics involved, so there are generally more issues with this engine than others. However, taken care of correctly (also assuming that the PO took care of it correctly), they'll take you to 300k+
*Included in the "etc etc etc etc" is several engine rebuilds, transmission replacements, and a huge amount of replacement parts.
Sent from my Droid Incredible